I'd say my patience as a consumer is at an end. I'm taking this back and getting Fallout 3.

I managed to do a Save and Quit multiple times before with no issues. My big Black Screen o' Death moment went down as the game autosaved following my quitting a bartending job.

Just had this happen to me after working a bartending job in Oakfield. I'd just finished my mission in the tattered spire, so I lost a 8 to 10 hours of gameplay. Loading up the game leads to a black screen that locks up my Xbox. Tried clearing the cache and had no success. This is a total deal breaker for me. Shame on not including multiple save ...